Thymosin Beta-4 5mg research peptide vial
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Thymosin Beta-4 5mg

Thymosin Beta-4

Purity 99%+
Form Lyophilized Powder
Molecular Weight 4921.0 g/mol
CAS Number See COA
Dosage: 5mg
Also known as: TB4, Tbeta4, Thymosin Beta 4
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Research Areas
Wound Healing Tissue Repair Cardiac Repair Anti-Inflammatory Hair Growth
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Overview

Thymosin beta-4 (Tbeta4) is a 43-amino-acid peptide and the most abundant member of the beta-thymosin family. It is expressed in virtually all nucleated cells at high concentrations (up to 0.4 mM). Its primary intracellular function is sequestration of G-actin monomers, regulating the dynamic balance between monomeric and filamentous actin that drives cell migration. Tbeta4's wound healing effects operate through multiple pathways: it promotes cell migration (via actin regulation), angiogenesis (through direct stimulation of endothelial cell differentiation), and anti-inflammatory activity (via NF-kB suppression). The landmark cardiac repair study by Bock-Marquette et al. in Nature showed Tbeta4 activates Akt/protein kinase B in cardiomyocytes, promoting cell survival after ischemic injury. The 5mg vial provides the same thymosin beta-4 compound as the 10mg TB-500 product at a lower quantity, suitable for smaller-scale research protocols. See the TB-500 10mg entry for comprehensive research details.

Mechanism of Action

Thymosin beta-4 (Tbeta4) is a 43-amino-acid peptide and the most abundant member of the beta-thymosin family. It is expressed in virtually all nucleated cells at high concentrations (up to 0.4 mM). Its primary intracellular function is sequestration of G-actin monomers, regulating the dynamic balance between monomeric and filamentous actin that drives cell migration. Tbeta4's wound healing effects operate through multiple pathways: it promotes cell migration (via actin regulation), angiogenesis (through direct stimulation of endothelial cell differentiation), and anti-inflammatory activity (via NF-kB suppression). The landmark cardiac repair study by Bock-Marquette et al. in Nature showed Tbeta4 activates Akt/protein kinase B in cardiomyocytes, promoting cell survival after ischemic injury. The 5mg vial provides the same thymosin beta-4 compound as the 10mg TB-500 product at a lower quantity, suitable for smaller-scale research protocols. See the TB-500 10mg entry for comprehensive research details.

Key Research Findings

  • Malinda et al. (1999) demonstrated Tbeta4 accelerates wound healing through enhanced cell migration and angiogenesis.
  • Bock-Marquette et al. (2004) showed Tbeta4 promotes cardiomyocyte survival through Akt activation after ischemic injury.
  • Philp et al. (2004) demonstrated Tbeta4 promotes corneal healing, hair follicle development, and angiogenesis.
  • Smart et al. (2007) showed Tbeta4 activates epicardial progenitor cells for cardiac regeneration.

Citations & References

1

Thymosin beta4 accelerates wound healing

Malinda KM, Sidhu GS, Mani H, et al. — J Invest Dermatol (1999)

2

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

Bock-Marquette I, Saxena A, White MD, et al. — Nature (2004)

3

Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development

Philp D, Goldstein AL, Kleinman HK. — Mech Ageing Dev (2004)

Dosage in Research

Rodent wound studies: 5-6 mcg topically or 150 mcg systemically. Equine studies: 10 mg loading dose. Cardiac studies in mice: 150 mcg intraperitoneally.

Dosage information is derived from published research literature and is presented for educational purposes only. This is not medical advice. All products are for laboratory research use only.

Storage & Handling

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.

Frequently Asked Questions

What is Thymosin Beta-4 5mg?
A lower-dose form of Thymosin Beta-4, studied for actin-binding activity, cell motility, and wound healing in tissue repair research.
What purity is your Thymosin Beta-4 5mg?
Our Thymosin Beta-4 5mg is manufactured at 99%+ purity, verified through third-party HPLC analysis and mass spectrometry. A Certificate of Analysis (COA) is included with every order.
How should I store Thymosin Beta-4 5mg?
Store lyophilized powder in a cool, dry place at 2-8°C away from direct light. Once reconstituted, refrigerate and use within the timeframe specified on the COA.
Is Thymosin Beta-4 5mg for human use?
No. Thymosin Beta-4 5mg is sold strictly for laboratory research use only. It is not intended for human consumption, veterinary use, or as a food additive. Products have not been evaluated by the FDA. Purchasers must be 21+ and confirm research use intent.
Where can I buy Thymosin Beta-4 5mg?
Thymosin Beta-4 5mg is available for purchase at researchvials.com. All orders include a COA and ship with temperature-controlled packaging.

Research Use Only

All products are intended for laboratory research and educational purposes only. Products have not been evaluated by the FDA and are not intended for human consumption, diagnosis, treatment, or prevention of any disease. Purchasers must be 21+ and confirm research use intent.