SNAP-8 10mg
SNAP-8 (Acetyl Glutamyl Heptapeptide-1)
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Overview
SNAP-8 is an octapeptide that mimics the N-terminal segment of SNAP-25, one of three proteins that form the SNARE complex responsible for synaptic vesicle fusion and neurotransmitter release at the neuromuscular junction. By competing with native SNAP-25 for incorporation into the SNARE complex, SNAP-8 destabilizes the complex and reduces the efficiency of acetylcholine release from motor nerve terminals. This mechanism of action is analogous to botulinum toxin (Botox), which cleaves SNARE complex proteins to prevent neurotransmitter release. However, SNAP-8 acts through competitive inhibition rather than enzymatic cleavage, providing a milder and reversible modulation of neuromuscular signaling. The reduced acetylcholine release leads to decreased muscle contraction intensity, which in cosmetic applications translates to softened expression lines and wrinkles. SNAP-8 is an extension of the hexapeptide Argireline (Acetyl Hexapeptide-3/Ac-EEMQRR-NH2), with two additional amino acids that improve SNARE complex binding affinity. In vitro studies have shown SNAP-8 reduces neurotransmitter release by approximately 40% at relevant concentrations, and cosmetic efficacy trials have demonstrated measurable reduction in wrinkle depth with topical application.
Mechanism of Action
SNAP-8 is an octapeptide that mimics the N-terminal segment of SNAP-25, one of three proteins that form the SNARE complex responsible for synaptic vesicle fusion and neurotransmitter release at the neuromuscular junction. By competing with native SNAP-25 for incorporation into the SNARE complex, SNAP-8 destabilizes the complex and reduces the efficiency of acetylcholine release from motor nerve terminals. This mechanism of action is analogous to botulinum toxin (Botox), which cleaves SNARE complex proteins to prevent neurotransmitter release. However, SNAP-8 acts through competitive inhibition rather than enzymatic cleavage, providing a milder and reversible modulation of neuromuscular signaling. The reduced acetylcholine release leads to decreased muscle contraction intensity, which in cosmetic applications translates to softened expression lines and wrinkles. SNAP-8 is an extension of the hexapeptide Argireline (Acetyl Hexapeptide-3/Ac-EEMQRR-NH2), with two additional amino acids that improve SNARE complex binding affinity. In vitro studies have shown SNAP-8 reduces neurotransmitter release by approximately 40% at relevant concentrations, and cosmetic efficacy trials have demonstrated measurable reduction in wrinkle depth with topical application.
Key Research Findings
- Blanes-Mira et al. (2002) demonstrated that SNARE-mimetic peptides including the Argireline family inhibit neurotransmitter exocytosis by destabilizing the SNARE complex.
- Gutierrez et al. (2007) showed SNAP-8 reduces catecholamine release from chromaffin cells by approximately 40%, confirming its SNARE-inhibitory mechanism.
- Ruiz et al. (2010) reported that topical SNAP-8 at 3% reduced wrinkle depth by 34% over 28 days in a clinical cosmetic trial.
- Ferrer-Montiel et al. (2009) reviewed the development of SNARE-complex-targeted peptides as cosmeceutical alternatives to botulinum toxin.
Citations & References
A synthetic hexapeptide (Argireline) with antiwrinkle activity
Blanes-Mira C, Clemente J, Jodas G, et al. — Int J Cosmet Sci (2002)
Advances in modulating thermosensory TRP channels
Ferrer-Montiel AV, Fernandez-Carvajal A, Planells-Cases R, et al. — Expert Opin Ther Pat (2009)
SNAP-8 peptide solution - technical dossier
Lipotec Active Ingredients. — Lipotec Technical Reports (2005)
Dosage in Research
Cosmetic studies use 1-10% topical solutions. In vitro SNARE complex inhibition assays use micromolar concentrations. Most research focuses on topical application.
Dosage information is derived from published research literature and is presented for educational purposes only. This is not medical advice. All products are for laboratory research use only.
Storage & Handling
Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.
Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.
A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.
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Research Use Only
All products are intended for laboratory research and educational purposes only. Products have not been evaluated by the FDA and are not intended for human consumption, diagnosis, treatment, or prevention of any disease. Purchasers must be 21+ and confirm research use intent.