Pinealon 20mg

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by Vladimir Khavinson as a brain-specific bioregulator. It belongs to the class of short peptide bioregulators that Khavinson's group has studied for over three decades. Pinealon is derived from the amino acid sequence analysis of brain tissue extracts and is designed to penetrate cells and interact directly with DNA to modulate gene expression. The proposed mechanism involves the peptide's ability to bind to specific DNA sequences in gene promoter regions, influencing transcription of genes involved in neuroprotection, antioxidant defense, and circadian regulation. Khavinson's group has demonstrated that short peptides (2-4 amino acids) can penetrate cell membranes and nuclear envelopes without receptor-mediated endocytosis, directly accessing chromatin. In vitro studies have shown pinealon protects cortical neurons against hypoxia-induced damage and oxidative stress. It has also been reported to normalize melatonin synthesis in pinealocytes and to regulate expression of genes involved in cell differentiation and apoptosis in neural tissue. However, it should be noted that much of the primary research originates from Khavinson's group in St. Petersburg, and the gene-regulatory mechanisms proposed for these short peptides remain somewhat controversial in the broader scientific community.

Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by Vladimir Khavinson as a brain-specific bioregulator. It belongs to the class of short peptide bioregulators that Khavinson's group has studied for over three decades. Pinealon is derived from the amino acid sequence analysis of brain tissue extracts and is designed to penetrate cells and interact directly with DNA to modulate gene expression. The proposed mechanism involves the peptide's ability to bind to specific DNA sequences in gene promoter regions, influencing transcription of genes involved in neuroprotection, antioxidant defense, and circadian regulation. Khavinson's group has demonstrated that short peptides (2-4 amino acids) can penetrate cell membranes and nuclear envelopes without receptor-mediated endocytosis, directly accessing chromatin. In vitro studies have shown pinealon protects cortical neurons against hypoxia-induced damage and oxidative stress. It has also been reported to normalize melatonin synthesis in pinealocytes and to regulate expression of genes involved in cell differentiation and apoptosis in neural tissue. However, it should be noted that much of the primary research originates from Khavinson's group in St. Petersburg, and the gene-regulatory mechanisms proposed for these short peptides remain somewhat controversial in the broader scientific community.

In vitro neuroprotection studies use nanomolar to micromolar concentrations. Russian clinical protocols use 10-20 mg per course. Specific dosing regimens vary by application.

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.