NAD+ research peptide vial
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NAD+

Nicotinamide Adenine Dinucleotide

Purity 98%+
Form Lyophilized Powder
Molecular Weight 663.43 g/mol
CAS Number See COA
Dosage: 1000mg/500mg
Also known as: NAD+, NAD, Coenzyme I
Sequence: Non-peptide dinucleotide
Research Areas
Aging Research Cellular Metabolism DNA Repair Neuroprotection Sirtuin Biology
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Overview

NAD+ is a fundamental coenzyme in cellular energy metabolism, serving as the primary electron carrier in mitochondrial oxidative phosphorylation and as an essential substrate for sirtuins (SIRT1-7), PARPs, and CD38/CD157 enzymes. NAD+ levels decline significantly with age, impairing sirtuin-mediated gene regulation, mitochondrial function, and DNA repair capacity. The 500mg product contains the same NAD+ compound as the 1000mg biofermented version at a lower quantity. See the NAD 1000mg entry for comprehensive research details on NAD+ biology, the role of NAD+ decline in aging, and the therapeutic potential of NAD+ restoration.

Mechanism of Action

NAD+ is a fundamental coenzyme in cellular energy metabolism, serving as the primary electron carrier in mitochondrial oxidative phosphorylation and as an essential substrate for sirtuins (SIRT1-7), PARPs, and CD38/CD157 enzymes. NAD+ levels decline significantly with age, impairing sirtuin-mediated gene regulation, mitochondrial function, and DNA repair capacity. The 500mg product contains the same NAD+ compound as the 1000mg biofermented version at a lower quantity. See the NAD 1000mg entry for comprehensive research details on NAD+ biology, the role of NAD+ decline in aging, and the therapeutic potential of NAD+ restoration.

Key Research Findings

  • Yoshino et al. (2011) showed NAD+ restoration normalizes glucose tolerance and mitochondrial function in aged mice.
  • Gomes et al. (2013) demonstrated declining NAD+ causes pseudohypoxia through disrupted SIRT1-HIF1alpha signaling.
  • Verdin (2015) reviewed NAD+ as a central regulator of aging, metabolism, and neurodegeneration.
  • Rajman et al. (2018) comprehensively reviewed the in vivo evidence for therapeutic NAD+ boosting.

Citations & References

1

Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

Yoshino J, Mills KF, Yoon MJ, Imai S. — Cell Metab (2011)

2

NAD+ in aging, metabolism, and neurodegeneration

Verdin E. — Science (2015)

3

Therapeutic potential of NAD-boosting molecules: the in vivo evidence

Rajman L, Chwalek K, Sinclair DA. — Cell Metab (2018)

Dosage in Research

IV NAD+ protocols in clinical settings use 250-750 mg infusions. The 500mg vial provides a standard research quantity.

Dosage information is derived from published research literature and is presented for educational purposes only. This is not medical advice. All products are for laboratory research use only.

Storage & Handling

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.

Frequently Asked Questions

What is NAD+?
Nicotinamide adenine dinucleotide at standard research concentration, studied for its central role in redox reactions, mitochondrial function, and sirtuin-mediated pathways.
What purity is your NAD+?
Our NAD+ is manufactured at 98%+ purity, verified through third-party HPLC analysis and mass spectrometry. A Certificate of Analysis (COA) is included with every order.
How should I store NAD+?
Store lyophilized powder in a cool, dry place at 2-8°C away from direct light. Once reconstituted, refrigerate and use within the timeframe specified on the COA.
Is NAD+ for human use?
No. NAD+ is sold strictly for laboratory research use only. It is not intended for human consumption, veterinary use, or as a food additive. Products have not been evaluated by the FDA. Purchasers must be 21+ and confirm research use intent.
Where can I buy NAD+?
NAD+ is available for purchase at researchvials.com. All orders include a COA and ship with temperature-controlled packaging.

Research Use Only

All products are intended for laboratory research and educational purposes only. Products have not been evaluated by the FDA and are not intended for human consumption, diagnosis, treatment, or prevention of any disease. Purchasers must be 21+ and confirm research use intent.