5-amino-1mq

5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), a cytoplasmic enzyme that methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor. NNMT is highly expressed in adipose tissue and liver, and its activity increases with obesity. By consuming nicotinamide, NNMT reduces the availability of substrate for NAD+ biosynthesis through the salvage pathway. Inhibiting NNMT with 5-Amino-1MQ has two beneficial metabolic consequences. First, it increases the pool of nicotinamide available for NAD+ synthesis, thereby boosting cellular NAD+ levels. Since NAD+ is essential for sirtuin activity and mitochondrial function, this effectively enhances metabolic efficiency. Second, NNMT inhibition reduces the consumption of SAM, increasing the SAM/SAH (S-adenosylhomocysteine) ratio, which influences cellular methylation reactions broadly. Naughton et al. at the University of Texas demonstrated that NNMT inhibition with 5-Amino-1MQ reduced adiposity in diet-induced obese mice without affecting food intake, suggesting direct metabolic effects on fat tissue rather than appetite suppression. The compound also reduced adipocyte size, decreased lipid accumulation, and increased energy expenditure, consistent with the expected effects of enhanced NAD+ availability and improved metabolic efficiency.

5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), a cytoplasmic enzyme that methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor. NNMT is highly expressed in adipose tissue and liver, and its activity increases with obesity. By consuming nicotinamide, NNMT reduces the availability of substrate for NAD+ biosynthesis through the salvage pathway. Inhibiting NNMT with 5-Amino-1MQ has two beneficial metabolic consequences. First, it increases the pool of nicotinamide available for NAD+ synthesis, thereby boosting cellular NAD+ levels. Since NAD+ is essential for sirtuin activity and mitochondrial function, this effectively enhances metabolic efficiency. Second, NNMT inhibition reduces the consumption of SAM, increasing the SAM/SAH (S-adenosylhomocysteine) ratio, which influences cellular methylation reactions broadly. Naughton et al. at the University of Texas demonstrated that NNMT inhibition with 5-Amino-1MQ reduced adiposity in diet-induced obese mice without affecting food intake, suggesting direct metabolic effects on fat tissue rather than appetite suppression. The compound also reduced adipocyte size, decreased lipid accumulation, and increased energy expenditure, consistent with the expected effects of enhanced NAD+ availability and improved metabolic efficiency.

Mouse studies used 2-20 mg/kg IP daily. Cell culture studies use 1-100 micromolar concentrations. Human dosing protocols are not established.

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.