KissPeptin (10mg)

Kisspeptin is a neuropeptide product of the KISS1 gene that serves as a critical regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It was discovered in 2003 by two independent groups (de Roux et al. and Seminara et al.) who identified loss-of-function mutations in the kisspeptin receptor (GPR54/KISS1R) as a cause of hypogonadotropic hypogonadism — failure to undergo puberty due to absent GnRH signaling. Kisspeptin is the most potent known stimulator of gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin neurons in the hypothalamic arcuate nucleus and anteroventral periventricular nucleus express KISS1R and project directly to GnRH neurons. Upon kisspeptin binding, KISS1R activation stimulates GnRH neurons to release GnRH into the portal circulation, which in turn triggers LH and FSH release from the anterior pituitary. Kisspeptin-10 is the minimal bioactive C-terminal fragment (amino acids 45-54 of the full 54-amino-acid kisspeptin-54) that retains full KISS1R binding and activation. Research has explored kisspeptin as a diagnostic tool for reproductive disorders and as a potential therapeutic for infertility. Dhillo et al. demonstrated that kisspeptin-54 infusion potently stimulates LH secretion in healthy men and women, and subsequent work has explored its use in triggering oocyte maturation for IVF without the risk of ovarian hyperstimulation syndrome.

Kisspeptin is a neuropeptide product of the KISS1 gene that serves as a critical regulator of the hypothalamic-pituitary-gonadal (HPG) axis. It was discovered in 2003 by two independent groups (de Roux et al. and Seminara et al.) who identified loss-of-function mutations in the kisspeptin receptor (GPR54/KISS1R) as a cause of hypogonadotropic hypogonadism — failure to undergo puberty due to absent GnRH signaling. Kisspeptin is the most potent known stimulator of gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin neurons in the hypothalamic arcuate nucleus and anteroventral periventricular nucleus express KISS1R and project directly to GnRH neurons. Upon kisspeptin binding, KISS1R activation stimulates GnRH neurons to release GnRH into the portal circulation, which in turn triggers LH and FSH release from the anterior pituitary. Kisspeptin-10 is the minimal bioactive C-terminal fragment (amino acids 45-54 of the full 54-amino-acid kisspeptin-54) that retains full KISS1R binding and activation. Research has explored kisspeptin as a diagnostic tool for reproductive disorders and as a potential therapeutic for infertility. Dhillo et al. demonstrated that kisspeptin-54 infusion potently stimulates LH secretion in healthy men and women, and subsequent work has explored its use in triggering oocyte maturation for IVF without the risk of ovarian hyperstimulation syndrome.

Human studies used IV infusions of kisspeptin-54 at 0.1-3.1 nmol/kg/hr. Kisspeptin-10 bolus studies used 0.3-10 nmol/kg IV. Subcutaneous dosing has also been explored.

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.