IGF-1 LR3 1mg

IGF-1 LR3 (Long Arginine 3 Insulin-like Growth Factor 1) is a synthetic analogue of human IGF-1 with two key modifications: the glutamic acid at position 3 is replaced with arginine (R3), and a 13-amino-acid N-terminal extension peptide is added. These modifications dramatically reduce binding to IGF-binding proteins (IGFBPs), which normally sequester over 95% of circulating IGF-1. The result is a form of IGF-1 with greatly enhanced bioavailability and potency. Like native IGF-1, IGF-1 LR3 binds and activates the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase that signals through the PI3K/Akt and Ras/MAPK pathways to promote cell survival, proliferation, and growth. The PI3K/Akt pathway is particularly important for muscle protein synthesis (via mTOR activation) and anti-apoptotic signaling. The Ras/MAPK pathway drives cell proliferation and differentiation. Because IGF-1 LR3 has dramatically reduced IGFBP binding, a much larger fraction of the administered peptide remains free and biologically active. In cell culture, IGF-1 LR3 is significantly more potent than native IGF-1 at promoting cell proliferation. This property makes it widely used as a cell culture supplement and a research tool for studying IGF-1 receptor signaling. In vivo, the reduced IGFBP binding gives IGF-1 LR3 an extended effective half-life and greater tissue distribution compared to native IGF-1.

IGF-1 LR3 (Long Arginine 3 Insulin-like Growth Factor 1) is a synthetic analogue of human IGF-1 with two key modifications: the glutamic acid at position 3 is replaced with arginine (R3), and a 13-amino-acid N-terminal extension peptide is added. These modifications dramatically reduce binding to IGF-binding proteins (IGFBPs), which normally sequester over 95% of circulating IGF-1. The result is a form of IGF-1 with greatly enhanced bioavailability and potency. Like native IGF-1, IGF-1 LR3 binds and activates the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase that signals through the PI3K/Akt and Ras/MAPK pathways to promote cell survival, proliferation, and growth. The PI3K/Akt pathway is particularly important for muscle protein synthesis (via mTOR activation) and anti-apoptotic signaling. The Ras/MAPK pathway drives cell proliferation and differentiation. Because IGF-1 LR3 has dramatically reduced IGFBP binding, a much larger fraction of the administered peptide remains free and biologically active. In cell culture, IGF-1 LR3 is significantly more potent than native IGF-1 at promoting cell proliferation. This property makes it widely used as a cell culture supplement and a research tool for studying IGF-1 receptor signaling. In vivo, the reduced IGFBP binding gives IGF-1 LR3 an extended effective half-life and greater tissue distribution compared to native IGF-1.

Cell culture: 50-100 ng/mL as a culture medium supplement. In vivo rodent studies: 1-10 mcg/animal SC or IP. The 1mg vial provides material for extensive cell culture or animal study protocols.

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.