Hexarelin Acetate 5mg research peptide vial
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Hexarelin Acetate 5mg

Hexarelin Acetate

Purity 98%+
Form Lyophilized Powder
Molecular Weight 887.04 g/mol
CAS Number See COA
Dosage: 5mg
Also known as: Hexarelin, Examorelin, HEX
Sequence: His-D-2-methylTrp-Ala-Trp-D-Phe-Lys-NH2
Research Areas
Growth Hormone Release Cardiac Protection GHS-R1a Signaling CD36 Binding
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Overview

Hexarelin is a synthetic hexapeptide growth hormone secretagogue (GHS) derived from GHRP-6 with enhanced potency and stability. It binds the ghrelin receptor (GHS-R1a) and also interacts with the scavenger receptor CD36, giving it a unique dual-receptor pharmacological profile among GH secretagogues. At the pituitary, hexarelin activates GHS-R1a to stimulate GH release through phospholipase C-mediated calcium signaling. Unlike ipamorelin, hexarelin is not selective for GH — it also stimulates ACTH, cortisol, and prolactin release, albeit to varying degrees. Its GH-releasing potency is approximately 1.5 times that of GHRP-6 in equimolar comparisons. Hexarelin's interaction with CD36 receptors on cardiac cells has generated significant interest in cardioprotective research. Bhatt et al. demonstrated that hexarelin reduces infarct size and improves cardiac function after ischemia-reperfusion injury in animal models, effects that are independent of GH release and mediated through CD36. This cardiac activity is unique among GH secretagogues and involves modulation of mitochondrial function and apoptotic pathways in cardiomyocytes.

Mechanism of Action

Hexarelin is a synthetic hexapeptide growth hormone secretagogue (GHS) derived from GHRP-6 with enhanced potency and stability. It binds the ghrelin receptor (GHS-R1a) and also interacts with the scavenger receptor CD36, giving it a unique dual-receptor pharmacological profile among GH secretagogues. At the pituitary, hexarelin activates GHS-R1a to stimulate GH release through phospholipase C-mediated calcium signaling. Unlike ipamorelin, hexarelin is not selective for GH — it also stimulates ACTH, cortisol, and prolactin release, albeit to varying degrees. Its GH-releasing potency is approximately 1.5 times that of GHRP-6 in equimolar comparisons. Hexarelin's interaction with CD36 receptors on cardiac cells has generated significant interest in cardioprotective research. Bhatt et al. demonstrated that hexarelin reduces infarct size and improves cardiac function after ischemia-reperfusion injury in animal models, effects that are independent of GH release and mediated through CD36. This cardiac activity is unique among GH secretagogues and involves modulation of mitochondrial function and apoptotic pathways in cardiomyocytes.

Key Research Findings

  • Ghigo et al. (1994) characterized hexarelin as a potent GH secretagogue with activity via subcutaneous, intranasal, and oral routes in humans.
  • Bisi et al. (1999) demonstrated that chronic hexarelin administration does not desensitize pituitary GH release over 16 weeks in elderly subjects.
  • Locatelli et al. (1999) showed hexarelin's cardioprotective effects are mediated through CD36 receptors, independent of GH release.
  • Mao et al. (2014) demonstrated hexarelin protects against cardiac ischemia-reperfusion injury through CD36-dependent mitochondrial function preservation.

Citations & References

1

Growth hormone-releasing peptides

Ghigo E, Arvat E, Muccioli G, et al. — Eur J Endocrinol (1997)

2

Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans

Bisi G, Podio V, Valetto MR, et al. — J Endocrinol Invest (1999)

3

Growth hormone-independent cardioprotective effects of hexarelin in the rat

Locatelli V, Rossoni G, Schweiger F, et al. — Endocrinology (1999)

Dosage in Research

Human studies used 1-2 mcg/kg IV or SC. Cardioprotective studies in rats used 50-200 mcg/kg. Dose-response studies for GH release used 0.5-2 mcg/kg.

Dosage information is derived from published research literature and is presented for educational purposes only. This is not medical advice. All products are for laboratory research use only.

Storage & Handling

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.

Frequently Asked Questions

What is Hexarelin Acetate 5mg?
A synthetic hexapeptide growth hormone secretagogue that acts through the ghrelin receptor (GHS-R1a), studied for potent GH release and cardioprotective properties in research models.
What purity is your Hexarelin Acetate 5mg?
Our Hexarelin Acetate 5mg is manufactured at 98%+ purity, verified through third-party HPLC analysis and mass spectrometry. A Certificate of Analysis (COA) is included with every order.
How should I store Hexarelin Acetate 5mg?
Store lyophilized powder in a cool, dry place at 2-8°C away from direct light. Once reconstituted, refrigerate and use within the timeframe specified on the COA.
Is Hexarelin Acetate 5mg for human use?
No. Hexarelin Acetate 5mg is sold strictly for laboratory research use only. It is not intended for human consumption, veterinary use, or as a food additive. Products have not been evaluated by the FDA. Purchasers must be 21+ and confirm research use intent.
Where can I buy Hexarelin Acetate 5mg?
Hexarelin Acetate 5mg is available for purchase at researchvials.com. All orders include a COA and ship with temperature-controlled packaging.

Research Use Only

All products are intended for laboratory research and educational purposes only. Products have not been evaluated by the FDA and are not intended for human consumption, diagnosis, treatment, or prevention of any disease. Purchasers must be 21+ and confirm research use intent.