AOD 9604 (5mg)

AOD-9604 is a modified fragment of human growth hormone (hGH) spanning amino acids 176-191, with an added tyrosine at the N-terminus to enhance stability. It was developed to isolate the lipolytic (fat-burning) activity of growth hormone from its growth-promoting and diabetogenic effects. The peptide stimulates lipolysis and inhibits lipogenesis through a mechanism distinct from the GH receptor, and notably does not induce IGF-1 production or affect blood glucose homeostasis. The mechanism appears to involve activation of beta-3 adrenergic receptor-related pathways in adipose tissue. Research by Ng and colleagues demonstrated that AOD-9604 mimics the way natural growth hormone regulates fat metabolism — it stimulates the breakdown of stored triglycerides in adipocytes while simultaneously blocking the formation of new fat. Importantly, studies have confirmed it does not compete with hGH for receptor binding, suggesting it acts through an independent signaling pathway. More recent research has explored AOD-9604's effects on cartilage. Studies have shown it may promote proteoglycan and collagen synthesis in chondrocytes, opening potential applications in osteoarthritis research beyond its original anti-obesity focus.

AOD-9604 is a modified fragment of human growth hormone (hGH) spanning amino acids 176-191, with an added tyrosine at the N-terminus to enhance stability. It was developed to isolate the lipolytic (fat-burning) activity of growth hormone from its growth-promoting and diabetogenic effects. The peptide stimulates lipolysis and inhibits lipogenesis through a mechanism distinct from the GH receptor, and notably does not induce IGF-1 production or affect blood glucose homeostasis. The mechanism appears to involve activation of beta-3 adrenergic receptor-related pathways in adipose tissue. Research by Ng and colleagues demonstrated that AOD-9604 mimics the way natural growth hormone regulates fat metabolism — it stimulates the breakdown of stored triglycerides in adipocytes while simultaneously blocking the formation of new fat. Importantly, studies have confirmed it does not compete with hGH for receptor binding, suggesting it acts through an independent signaling pathway. More recent research has explored AOD-9604's effects on cartilage. Studies have shown it may promote proteoglycan and collagen synthesis in chondrocytes, opening potential applications in osteoarthritis research beyond its original anti-obesity focus.

Preclinical studies have used doses ranging from 50-500 mcg/kg in animal models. A Phase IIb human clinical trial studied oral doses of 1 mg, 5 mg, 10 mg, and 20 mg daily over 12 weeks.

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.