AICAR 50mg

AICAR (5-aminoimidazole-4-carboxamide riboside, also known as acadesine) is a naturally occurring nucleoside that is an intermediate in de novo purine biosynthesis. When administered exogenously, AICAR is taken up by cells and phosphorylated by adenosine kinase to form ZMP (AICAR monophosphate), which is a direct allosteric activator of AMP-activated protein kinase (AMPK). AMPK is the master cellular energy sensor that responds to low ATP/high AMP ratios. When activated, AMPK switches on catabolic pathways that generate ATP (fatty acid oxidation, glucose uptake, autophagy) while switching off ATP-consuming anabolic pathways (protein synthesis, lipogenesis, gluconeogenesis). AICAR mimics a low-energy state in the cell, activating AMPK without actually depleting cellular ATP. Narkar et al. published a landmark paper in Cell (2008) showing that AICAR enhanced running endurance by 44% in sedentary mice without any exercise training. This was the first demonstration that a pharmacological AMPK activator could mimic specific endurance exercise benefits, earning AICAR the designation as an 'exercise mimetic.' AICAR also has clinical research history: it was studied in Phase III trials (AMISTAD) for reducing ischemia-reperfusion injury during cardiac surgery.

AICAR (5-aminoimidazole-4-carboxamide riboside, also known as acadesine) is a naturally occurring nucleoside that is an intermediate in de novo purine biosynthesis. When administered exogenously, AICAR is taken up by cells and phosphorylated by adenosine kinase to form ZMP (AICAR monophosphate), which is a direct allosteric activator of AMP-activated protein kinase (AMPK). AMPK is the master cellular energy sensor that responds to low ATP/high AMP ratios. When activated, AMPK switches on catabolic pathways that generate ATP (fatty acid oxidation, glucose uptake, autophagy) while switching off ATP-consuming anabolic pathways (protein synthesis, lipogenesis, gluconeogenesis). AICAR mimics a low-energy state in the cell, activating AMPK without actually depleting cellular ATP. Narkar et al. published a landmark paper in Cell (2008) showing that AICAR enhanced running endurance by 44% in sedentary mice without any exercise training. This was the first demonstration that a pharmacological AMPK activator could mimic specific endurance exercise benefits, earning AICAR the designation as an 'exercise mimetic.' AICAR also has clinical research history: it was studied in Phase III trials (AMISTAD) for reducing ischemia-reperfusion injury during cardiac surgery.

Mouse exercise studies used 500 mg/kg/day for 4 weeks. Cardiac surgery trials used IV infusions of 0.1 mg/kg/min. Cell culture studies use 0.5-2 mM.

Store lyophilized (freeze-dried) powder at -20°C to 4°C in a dry environment protected from light. Unreconstituted peptide is stable for extended periods when stored properly.

Once reconstituted with bacteriostatic water or an appropriate solvent, store at 2-8°C and use within the timeframe specified on the Certificate of Analysis. Avoid repeated freeze-thaw cycles.

A Certificate of Analysis documenting purity, identity, and recommended storage conditions is included with every order.